GLG News Analyses of the following article:

Phase III Study of Capecitabine Plus Oxaliplatin Compared With Continuous-Infusion Fluorouracil Plus Oxaliplatin As First-Line Therapy in Metastatic Colorectal Cancer: Final Report of the Spanish Cooperative Group for the Treatment of Digestive Tumors Trial

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Published at: jco.ascopubs.org

Can Xeloda Triumph 5-FU? Yes! Will It? That's Another Story!

September 21, 2007

GLG Expert Contributor

Can Xeloda replace 5-FU, it sure can! Though, I'm just as sure that it won't and data (in terms of efficacy) is not the reason for Roche's woes! The Spanish data has just added another brick in the wall of data supporting Roche's battle to get Xeloda to overtake 5-FU, though it’s already a pretty well developed wall! If anything the lukewarm reception that awaits the data further suggests that Roche has missed the boat on Xeloda!

Donald Fleming, Director of the Cancer Care Center

Donald FlemingDirector of the Cancer Care Center DAVIS HEALTH SYSTEM, INC. 
          What is a GLG Leader?|The Gerson Lehrman Group&reg; (GLG) Leader Program<sup>SM</sup> is our premium Member Program<sup>SM</sup>. Those identified as GLG Leaders are in the top 5% of GLG CouncilRank and have an exclusivity agreement with GLG.

Xeloda Suplants 5FU

September 20, 2007

Xeloda has proven equal to infusional 5FU in recent colorectal cancer trial Xeloda is an oral agent versus iv 5FU and is therefore prefered therapy Xeloda has a diffrenet toxicity profile than infusional 5FU

Capecitabine-replaces infusional 5FU?

September 19, 2007

GLG Expert Contributor

Capecitabine can replace 5FU in the FOLFOX program for CRC (And by inference in all infusional programs for 5FU)

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