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Lipitor sales

December 5, 2008

Analysis of:Patients Taking Lipitor Had a Significantly Reduced Risk of Cardiovascular Events Compared with Patients Taking Simvastatin, New Observational Study Shows | pharmalive.com

The results of this observational study suggested Lipitor was more effective than simvastatin. This is not terribly surprising. Lipitor is the more potent statin, even allowing for dosing differences. Observational studies, however, have inherent weaknesses in that we cannot be sure that the patients were really comparable between the two treatments. Notably an even more potent statin, Crestor (rosuvastatin) was not included in the analysis. Given Pfizer's ferocious marketing engine, this study is likely to be heavily promoted by Pfizer, and its importance exaggerated.

Exenatide and a TZD

April 9, 2007

Analysis of:The Effect of Adding Exenatide to a Thiazolidinedione in Suboptimally Controlled Type 2 Diabetes | www.annals.org

This article confirms what many of us had expected. Enenatide works, as predicted, with a TZD with comparable reductions in A1c to other settings. Many physicians had been previously using the combination "off label" The study allowed the label to be modified to include the combination, and it is now actively being promoted by the durg company.

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