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Importance of the rapid C.Difficile DNA test

July 22, 2009

Analysis of:Rapid DNA Test to Detect Clostridium difficile Infection Approved by FDA Today | www.medscape.com

Availability of this test is an important advance.C.Difficile colitis has drammatically increased in frequency and severity and results in major health care costs.Early diagnosis of the infection with early treatment will improve prognosis.I would expect that the test should be rapidly introduced into clinical practice

Why is the risk of colorectal cancer not higher in Asians?

January 2, 2009

Analysis of:Drinkers With The Alcohol Dehydrogenase 1C*1 Gene Are At Greater Risk Of Colorectal Cancer | www.medicalnewstoday.com

High blood acetaldehyde levels are associated with more liver and perhaps pancreatic damage and inflammation thus enhancing neoplasia. How would high blood acetaldehyde levels induce colorectal cancer? Also through inflammation. The alcohol dehydrogenase polymorphism is common in Asians yet there is not a concomitant increase in colorectal cancer. This association is interesting but requires experimental proof.

blood microRNA testing for cancer

January 2, 2009

Analysis of:Rosetta Genomics Announces Commercial Availability of Its Third MicroRNA-Based Diagnostic Test: miRview(TM) meso | phx.corporate-ir.net

Previous 'simple' molecular tests for cancer have ussually not worked out in practice. Although microRNA's have cellular control function for multiple genes it is premature to believe that these tests will be more successful.

cancer incidence falls drammatically after age 85

October 13, 2008

Analysis of:Task force: Colon cancer screenings can stop at 75 | news.yahoo.com

The best epidemiologic data states that the incidence of colorectal cancer as well as most other cancers falls drammatically after age 85. Thus screening for a dissappearing disease makes no sense. Also colorectal cancer takes an average of 8-10 years to develop so that screening for average risk individuals ,at least those who are deemed unlikely to survive till age 85 makes no sense.Thus only those over age 75 at increased risk should be screened.

Are physicians who represent plaintiffs any less biased than researchers working with a pharmaceutical company

April 21, 2008

Analysis of:Reports: Data on Vioxx was misused | www.usatoday.com

The authors of this study obtained the data while representing plaintiffs and their lawyers.Surely they come from a biased viewpoint and perhaps more biased than groups of researchers who have performed a study may not have written all of a final manuscript but had the chance to review it.

cllaboration between academia and industry

February 5, 2008

Analysis of:World class researchers in gene tie-up | www.businessweekly.co.uk

Collaboration between academia and the pharmaceutical industry in genetic studies of common diseases is to be lauded since the pharmaceutical makers have large data banks of human material.It is pertinent that the PI's in the specific studies cited in the article are from academia.

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