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LABA's Should Never Be first Line Therapy

December 11, 2008

FDA: Long-Acting Asthma Drugs Increase Asthma Risks | online.wsj.com

National asthma guidelines have been clear for years that single drug therapy with a LABA should be minimal.  Even with these long standing recommendations, LABA use has remained strong due to signifi9cant MD marketing.  Health plans and PBMs have a responsibility to implement electronic drug edits to minimize LABA use.

A Pill For Every Mouth

November 24, 2008

Are Costly Diabetes Pills Doing Any Good? | www.pharmalot.com

Our obsession with quick fixes and a lack of focus on lifestyle changes will provide sub-optimal results.  Without comparative effectiveness trials, there is no way to gauge the value of these new therapies.

Off Label Use Can Be Prevented

November 24, 2008

Use of Antipsychotics in Children Is Criticized | www.nytimes.com

Current PBM adjudication technology can stop a prescription from being a covered benefit when an atypical is being prescribed in the pediatric setting.  the  dispensing pharmacist would receive a prior authorization required message and a discussion with the prescribing MD would be required.  I did this when I was chief pharmacy officer.

Who can tolerate these doses and for how long?

November 13, 2008

CRESTOR Demonstrates Dramatic CV Risk Reduction in a Large Statin Outcomes Study | www.astrazeneca.com

20 mg of Crestor is a high dose associated in many studies with a higher incidence of side effects.  Since compliance is historically poor with any maintenance medication, it will be interesting to see if patients with normal LDL with stay compliant with this statin or any statin in the higher doses in a real world population.  It is also important to note that simvastatin, another super-statin is available as a generic and should be used 1st line more often than it is today.

Science vs Marketing

November 12, 2008

Pharma need not worry too much about President Obama | www.biovalley.ch

The Obama vision is based on science driving the prescription process.  As such, DTC advertising and the sampling of brand name medications will either be restricted or incentives provided to MDs to replace samples with vouchers.  PBMs will be required to be absolutely transparent and Medicare Part D will require transparency on rebates and a minimum rebate for the dual eligibles, at a minimum.

PhRMA Fairy Tale is Over

July 21, 2008

Drug groups prescribe for future growth | www.ft.com

Drug manufacturers must evolve to an outcomes based reimbursement schedule to gain formulary placement and avoid prior authorization and oher utilization management tools

A Pill For Every Mouth

July 11, 2008

8-Year-Olds on Statins? A New Plan Quickly Bites Back | www.nytimes.com

Dangers of over-medication.  Lack of long term studies.  lack of personal and parental responsibility

Different reimbursement systems for oral and infusion drugs corrupts the drug use process

July 10, 2008

Pricey Drugs Put Squeeze on Doctors | online.wsj.com

To enhance health care efficiency, MDs should not have to purchase and stock expensive biotech drugs in their office.  Drugs should be charged to the health plan or PBM and the drugs should arrive at the MDs office labeled for the particular patient

PBMs and Big PhRMA fiddle while the health care system burns

July 9, 2008

Drug groups prescribe for future growth | www.ft.com

Pricing constraints in the US such as Best Price legislation preclude innovative outcomes based solutions from being adopted.  CMS should provide waivers to Best Price to enable payers and drug innovators to engage in risk based contracts

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