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TB Vaccines in RSA

April 29, 2009

Analysis of:New TB vaccine candidate enters phase IIb proof-of-concept trial in South Africa | www.pharmabiz.com

TB poses a great threat in South Africa and in the world generally. South Africa has declared TB in South Africa as having reached a state of emergency and therefore is a crisis.It is therefore very crucial to ackowledge and support such initiatives especially that seeks to provide prevention efforts towards the spread of TB.I do not have documentation or background information to this clinical trial but I have couple of questions mainly for the Principal Investigator or even a Study Director. My questions are as follows:1. What are the reasons behind choosing Cape Town as a study site because KZN mainly the Ethekwini District has the highest number of PTB cases as well those of MDR cases.2. With regards to the age range of the study participants are they also considering HIV factor, those kids who might be infected with HIV, what implications will then their participation pose on their health in terms of drug resistance 3. Are they also considering other strains of TB other than PTB

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