Dr. Paul Chen MD

Ophthalmologist, North County Laser Eye Associates

GLG News by Dr. Paul Chen MD, Ophthalmologist

Analyses are solely the work of the authors and have not been edited or endorsed by GLG.

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Cell Transfer Device for Corneal Wound Healing

July 25, 2007

Analysis of:New Method Of Adult Stem Cell Growth Treats Cornea Disorders | www.sciencedaily.com

I have been working on a cell transfer device designed to optimize wound healing after PRK laser vision correction. Essentially, we plan to coat a silicone hydrogel contact lens with a thin dissolvable layer of collagen on the concave surface. Cultured epithelial cells would be seeded onto the collagen layer, and the device would be placed onto the human eye after PRK laser vision correction. Tissue adhesive or sutures would be used to secure the peripheral portion of the device onto the eye. Collagenases in the tear film would dissolve the collagen layer, similar to their action upon collagen shields. The live epithelial sheet would transfer onto the corneal stroma and adhere after 24-72 hours. The contact lens secured to the eye would protect the epithelial sheet while allowing the patient to see as he/she was healing. The contact lens would be removed after the epithelium was successfully transferred.

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