GLG News by Physicians who Implant Collamend for Hernia Repair (US)

Keith AllenDirector, Cardiothoracic Vascular Surgery ResearchMid America Heart & Lung Surgeons, PC

Drug Eluting Stents:The Next Vioxx

December 14, 2006

Analysis of:Trading restenosis for Thrombosis? New questions about drug-eluding stents. | content.nejm.org

1. DES whether used on or off label will likely require life long anticoagulation with Plavix like drugs.

2. The incidence of late thrombosis is significant when anticoagulation is interrupted for events such as elective surgery.

3. Unlike restenosis following insertion of a bare metal stent which rarely results in death to the patient, late thrombosis following use of a DES results in a 50% mortality.

4.  Hints of this problem were present during FDA presentations prior to DES approval which may lead to significant liability as this problem becomes more apparent.

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